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KMID : 0043320070300081008
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Archives of Pharmacal Research
2007 Volume.30 No. 8 p.1008 ~ p.1013
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Influence of Water Soluble Additives and HPMCP on Drug Release from Surelease®-coated Pellets Containing Tamsulosin Hydrochloride
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Kim Min-Soo
Kim Jeong-Soo
Kang Sun-Ho
Yoo Yeon-Hee
Lee Si-Beum
Park Jeong-Sook
Woo Jong-Soo
Hwang Sung-Joo
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Abstract
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The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease® for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease® or Surelease® containing HPMC, PEG 4000, mannitol and HPMCP (20% w/ w). In case of HPMC and PEG 4000 as additives into Surelease® film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease® as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease® showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease® based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.
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KEYWORD
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Drug release, Surelease®, HPMCP, HPMC, PEG 4000, Mannitol
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